– ABOUT
Sepsis
Infectious diseases are the second most important cause of death globally after heart disease, and kill more people than cancer. Severe sepsis and septic shock have a mortality rate of 20-40% in the setting of optimal resuscitation in wealthy countries and are responsible for the loss of millions of health dollars and tens of thousands of lives every year in Australia. Antibiotic intervention remains one of the most powerful and cost-effective medical interventions but is under severe threat from antibiotic resistance.
Analysis suggests that resistant pathogens may spread through the co-evolution of increased virulence, crucial in disseminating resistant strains. A comprehensive grasp of invasiveness is vital for developing novel clinical management methods, including strategies to diminish virulence without fostering antimicrobial resistance. Achieving this necessitates collaborative efforts by multidisciplinary teams to pinpoint shared pathogenic pathways for the early diagnosis, treatment, and prevention of life-threatening bacterial infections.
This Bioplatforms Australia Framework Data Initiative has been led since 2019 by Prof Mark Walker from the University of Queensland and has brought together researchers from several leading Australian research-intensive universities including the University of Sydney, the University of Melbourne, Monash University, University of New South Wales, University of Technology Sydney, and the University of Adelaide.
The data from this initiative has been published and is publicly accessible from Nature Communications.
OBJECTIVES
The creation of referential multi-‘omics data resources through the Antibiotic Resistant Pathogens Framework Data Initiative aims to:
- Understand pathogen virulence and resistance: study the co-evolution of virulence and antibiotic resistance in pathogens to develop new clinical management strategies.
- Develop new diagnostic and treatment approaches: identify common pathogenic pathways to enhance early diagnosis, treatment, and prevention of life-threatening bacterial infections.
- Foster multidisciplinary collaboration: coordinate multidisciplinary teams across leading Australian universities to address antibiotic resistance.
- Build a multi-omics data platform: develop an open multi-omics data platform to support Health and Life Science researchers with data storage, integration, analysis, and sharing.
DATA
For further information and to view and access initiative data, please go to the Bioplatforms Australia Data Portal.
KEY INFORMATION
ACKNOWLEDGEMENT INFORMATION
Bioplatforms Initiative DOI: https://doi.org/10.25953/y4w5-ck87
Umbrella Bioproject ID: PRJNA1098045
Please use this ID when submitting any derived data to a database that is a member of the International Nucleotide Sequence Database Collaboration (INSDC), such as GenBank/NCBI, ENA or DDBJ.
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Citation Guidelines
To cite the general initiative:
Antibiotic Resistant Pathogens, 2019, https://doi.org/10.25953/y4w5-ck87
To cite a specific dataset:
The Antibiotic Resistant Pathogens, 2019, https://doi.org/10.25953/y4w5-ck87, [year-of-data-download], [full dataset title], [dataset-access-URL], accessed [date-of-access].
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Acknowledgement Statement
We would like to acknowledge the contribution of the Antibiotic Resistant Pathogens Consortium in the generation of data used in this publication. The Initiative is supported by funding from Bioplatforms Australia, enabled by the Commonwealth Government National Collaborative Research Infrastructure Strategy (NCRIS).
If relevant, also credit other organisations involved in the collection of the particular dataset you are using, as listed in the ‘project_lead’ and ‘project_collaborators’ in the metadata record.
CONTACT US
Program Manager
Mabel Lum – Bioplatforms Australia
mlum@bioplatforms.com
Project Lead
Mark Walker – The University of Queensland
mark.walker@uq.edu.au
General Manager – Science Programs
Sarah Richmond – Bioplatforms Australia
srichmond@bioplatforms.com