Melanoma Framework Data Initiative

Melanoma in Australia represents a major, unsolved public health challenge.

It remains one of the leading cancer killers, especially of young and middle-aged adults. This is partly because prognosis remains poor and largely unpredictable for all but early stage disease, and there are essentially no effective treatments for advanced disease.

However, after decades of stagnation, recent therapeutic advances in melanoma seem on the horizon. Recent investigation into the genetic basis of the disease has enabled the discovery of therapeutic agents that specifically target this cancer type. As ultra violet light, the causal agent of melanoma, is such a potent carcinogen this cancer type contains many different mutations. The generation of biomolecular datasets characterising melanoma tumours will aid in the determination of the ‘driver’ mutations behind this disease and aid in the development of further therapeutics.

This Bioplatforms Australia Framework Data Initiative is led by Professor Graham Mann from The University of Sydney in partnership with Queensland Institute of Medical Research, Westmead Millennium Institute, Melanoma Institute Australia, the John Curtin School of Medical Research, Peter MacCallum Cancer Centre (Melbourne Melanoma Project), Ludwig Institute for Cancer Research, Western Australian Institute for Medical Research and Edith Cowan University.

Data

The Melanoma Genomics Project aims to obtain whole genome sequences from approximately 500 melanoma patients.

The samples sequenced include brain, lymph, primary and metastatic tumours as well as cell line derived samples. The following coverage levels were generated for each sample:

  • 60x (or greater) for tumour samples
  • 40x for cell line samples
  • 40x for control blood samples

The project is now part of the International Cancer Genome Consortium. For further information on the data and access to the somatic variants for this study, go to: http://icgc.org/icgc/cgp/71/304/1012257

Due to ethics requirements, this data is only available upon request to the collaborators by authenticated researchers. This data has been made available through the International Cancer Genome Consortium. https://dcc.icgc.org/projects/MELA-AU

Project Details

  • Project Contacts

    Prof Graham Mann
    Project lead
    MBBS, PhD, FRACP
    Professor of Medicine, Westmead Clinical School
    Co-Director. Centre for Cancer Research, The Westmead Institute for Medical Research

    The University of Sydney
    graham.mann@sydney.edu.au

     

    Sarah Richmond

    General Manager, Science Program
    srichmond@bioplatforms.com

     

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